CIPF-UPV Joint Unit Disease Mechanisms and Nanomedicine

 Laboratory of Developmental Biology and Disease Models

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The original research interest of our group is to understand the basic mechanisms of the interplay of cell signaling and planar cell polarity during development. Our main experimental model is the developing limb of the fruitfly Drosophila melanogaster.

In addition, we are using our expertise in Genetics and Developmental Biology, and the experimental toolkit of Drosophila, to generate disease models to study the pathophysiology of neuromuscular diseases, with a particular interest in the Charcot-Marie-Tooth neuropathy.

In collaboration with other groups within the Programme of Genetic and Rare Diseases at the CIPF, we are contributing to the development of the Cellular Reprogramming Platform. This technological service aims to generate induced pluripotent stem (iPS) cells from a variety of sources as a tool for basic and translational research.